Thursday, 15 December 2011

Swine Flu (H1N1) - part : 1



What is H1N1 influenza virus?

The H1N1 influenza virus (human swine influenza or human swine flu) is a respiratory disease of humans caused by type A influenza virus. This particular strain has originated in swine, although it is now transmitted between people. Contact with swine is no longer a concern.


However, there is a theory that the large-scale breeding of pigs to satiate the ever-growing demands of pork-eating empires, both in the East and the West, may have a significant role to play in the development of new, disease-causing, influenza viruses. The biology is a little difficult to understand if you don’t have a working knowledge of virology, but I’ll try to keep it simple.
There are many different types of virus, that cause many different types of disease. Swine flu (H1N1), Bird Flu (H5N1), and the annual, seasonal flu, are all subtypes of the same species of virus: Influenza A. As the names “bird flu” and “swine flu” suggest, various strains of influenza A are capable of infecting multiple animal species, in addition to man.
There is reason to believe that all forms of the influenza A virus may be avian in origin – however, generally speaking, strains of avian influenza do not replicate well in humans. So how does the virus make the species jump from birds to people? This is where the pig comes in.
As pigs can be simultaneously co-infected with avian and human strains of influenza, they may act as “mixing vessels” in which new strains of influenza A develop, with the potential to cause disease in humans. In fact, this latest strain of H1N1 has been determined to be a genetic mix of four different flu viruses: two porcine, one avian, and one human. See another representation at the bottom of post.
Therefore, the theory is simple: if the world didn’t eat as much pork, then there would be less demand to breed pigs in such large quantities, reducing the number of “mixing vessels”, thus slowing the rate of emergence of new influenza viruses capable of harming human health. (This is where the “we told you so” dance is more justified).

How does H1N1 influenza virus spread?

Spread of H1N1 influenza virus also called H1N1 flu virus from person to person occurs in the same way as seasonal flu, which is mainly spread person to person through coughing or sneezing by people infected with the influenza virus. People may become infected by touching something with flu viruses or germs on it and then touching their mouth or nose. Germs on hard surfaces, such as counters and doorknobs, can be picked up on hands and spread to the respiratory system when people touch their mouth or nose. It is important to wash your hands frequently.


Incubation period

The imcubation period is the time between the moment a person is infected with the H1N1 virus and the time they start showing symptoms. People in the incubation period appear healthy, but they can sometimes pass the virus on to others.
Right now, the incubation period of H1N1 appears to be somewhere between one and seven days. It is likely most infected people start having symptoms within four days.
Infectious period

The infectious period is the time when a person with H1N1 is contagious, which means they can pass the virus on to others. The infectious period for H1N1 is not yet completely known. The US CDC considers it to:
  • Start one day before the person shows symptoms (gets sick)
  • Last for seven days after the symptoms appear
If infected people are still sick after seven days, they should be considered potentially contagious until their symptoms have disappeared. Children may be contagious for longer, up to 10 days.

H1N1 flu vaccine
There is no specific vaccine against the new A/H1N1 virus. However work is underway by several manufacturers to develop a safe and effective vaccine. It may be ready by October 2009.
In June, the vaccine-manufacturing company Novartis announced they had successfully produced the first batch of experimental H1N1 vaccine. It will undergo lab testing, and if all goes according to plan, should be ready for human testing by July. Should human tests prove satisfactory, the vaccine may be ready for licensing application by the northern hemisphere fall.
However, whether experts will recommend vaccination for the general public is a matter that is yet to be decided.
Seasonal influenza vaccine
Seasonal flu vaccines are those offered to the public every year as flu season approaches. They are designed to help prevent people during the upcoming, seasonal waves of flu activity.
Generally, most people should get a flu shot every year as a good health practice. In the current situation, it is still recommended that people who have not had an annual flu vaccination should consider having one to prevent regular seasonal flu.
It is unknown whether the current seasonal flu vaccine provides any protection against the strain of H1N1 flu currently circulating. Most likely, it is not effective against the new virus.
Many of the people who have gotten H1N1 flu in the USA had not had a seasonal flu vaccine. However, at least one case had been vaccinated, in October 2008. He got sick with H1N1 flu in early April, had a mild illness and recovered.
Other vaccinations
As a general good health practice, people should ensure their routine vaccinations are up-to-date. This includes pneumocococcal vaccination for certain adults: those over 65, people with serious long term health conditions and people whose immune systems are compromised due to transplants, cancer treatments, HIV/AIDS, etc.
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Swine Flu Treatments : Tamiflu (Oseltamivir) - Ralenza (Zanamivir)


As news of the A/1H1N Swine Flu pandemic spreads so do the rumours and fear. One persistently reoccurring statement is that existing flu treatments Tamiflu and RalenzaOseltamivir and Zanamivir) are not effective against the newest strain of Swine Flu. These rumours are not true; Tamiflu and Ralenza (Oseltamivir and Zanamivir) are considered to be effective and viable Swine Flue treatments.


CDC: Key Facts about Swine Flu
According to the CDC and WHO websites both Tamiflu and Ralenza (Oseltamivir and Zanamivir) can treat the A/1H1N Swine Flu strain. Both drugs are currently recommended as effective treatment options. What does not currently exist is a vaccine for

the A/1H1N Swine Flu strain. Swine Flu virus A/1H1N is a never before super flu that consists of 3 known swine flu strains, 3 known bird flu strains and a human flu virus. The combination of these strains makes the A/1H1N Swine Flu an unusual, but as of yet still treatable, strain of the flu. While there is no vaccine that combats these strains, alone or in combination the anti-viral medications Tamiflu and Ralenza (Oseltamivir and Zanamivir) are expected to be fully effective when administered quickly and properly. If you suspect you or somebody you know may be suffering from this new hybrid strain of Swine Flu seek treatment immediately. The sooner you are given Tamiflu or Ralenza, the better your chances of making a full recovery. All of the known US and Canadian cases of the A/1H1N Swine Flu are being treated with either Tamiflu or Ralenza (Oseltamivir or Zanamivir) and it is too soon to declare them ineffective. More will be known as the people currently suffering from the illness in Canada and the US start to recover.


How do Tamiflu and Ralenza (Oseltamivir and Zanamivir) work?

Both Tamiflu and Ralenza were designed to combat human strains of the influenza A and B viruses. They combat the flu by inhibiting the way that the virus spreads in the body. Tamiflu is given orally and Ralenza is administered via an inhaler. Both Tamiflu and Ralenza are approved for use in adults and children over the age of 7. It is important to note that the side effects of these drugs can be similar to Swine Flu symptoms and this may be to blame for anecdotal reports that the medications have been ineffective treatments. The CDC has no vaccine for A/H1N1 Swine Flu but it has expressed confidence in both Tamiflu and Ralenza.



Ralenza (Generic: Zanamivir)
Ralenza acts to bind the virus to its host cell stopping it from spreading to other cells by attaching to the neuraminidase protein in the virus itself. This effectively grounds the virus to its host cell rendering it incapable of spreading. Ralenza is given through a type of inhaler called a "diskhaler".

Tamiflu (Generic: Oseltamivir)
To be most effective Tamiflu must be administered within the first 48 hours of infection. The effectiveness of Tamiflu greatly diminishes after this point and the longer one goes without treatment the less effective the drug becomes. Tamiflu is only available by prescription or from a hospital.

Tamiflu (Oseltamivir) is given orally as either a pill or fruit flavoured syrup. The medication has been successful in treating aggressive Bird Flu strains in the past and is currently believed to be a viable option in treating the A/H1N1 Swine Flu strain.
During clinical trials in Vietnam Tamiflu was found to be mildly effective and results were considered to be disappointing. This may be where rumours that Tamiflu (Oseltamivir) is not effective against the new Swine Flu hybrid took root.

In the Vietnam clinical trials Tamiflu was administered late after infection, in most cases after the 48 hour period had elapsed, and this is believed to be the reason for lower than anticipated success rates.

The Vietnam clinical trial results only underline the importance of early treatment with Tamiflu. By declaring A/H1N1 Swine Flu a pandemic the CDC allowed medical professionals to start treatment when a patient is suspected to be suffering from the illness eliminating the need to test and verify before treatment.


Written by Tina Kells in http://www.nowpublic.com

What Is Amoxicillin?

moxicillin - better known by brand names such as Amoxil, Dispermox, Trimox, and Alphamox - is an antibiotic drug in the penicillin group that fights bacteria and bacterial infections.
Like other antibiotics in the penicillin category, amoxiciillin does not kill bacteria but rather prevents bacteria from forming walls that surround them, which are necessary for bacteria to multiply and survive.
Amoxicillin is only intended to treat bacterial infections and is not known to be effective against viral infections.

Since the patent for amoxicillin has expired, the drug is available as a generic in the form of several brand names.

What conditions are treated with amoxicillin?

Amoxicillin is prescribed to treat infections due to specific strains of common bacteria such as Streptococci, E. coli, Staphylococcus, H. pylori, P. mirabilis, H. influenzae, N. gonorrhoeae, and S. pneumoniae. These bacteria cause the following diseases:
  • Infections of the middle ear, nose and throat
  • Infections of the tonsils, throat, and larynx (laryngitis)
  • Infections of the bronchi (bronchitis) and lungs (pneumonia)
  • Urinary tract infections
  • Infections of the skin
  • Gonorrhea
Amoxicillin may also be prescribed to reduce the risk of duodenal ulcer recurrence in the gastrointestinal tract or to prevent an infection after surgery.

How is amoxicillin taken?

Amoxicillin is available in capsules, tablets, chewable tablets, powder for oral suspension, drops for oral suspension, and intravenous use. It can be taken with or without food. It is important to take amoxicillin for the entire length of time prescribed by your doctor even if symptoms get better before the prescription is finished. This will increase the effectiveness of immediate treatment and will decrease the likelihood that the bacteria will develop a resistance to the medicine.
Patients who miss a dose of amoxicillin should take the missed dose as soon as he or she remembers. If the time for the next dose is approaching, skip the missed dose and take the next dose at the scheduled time.

Taking extra medicine to make up for the missed dose is dangerous. It is possible to overdose on amoxicillin, and emergency medical attention may be required.
Often, amoxicillin is combined with lansoprazole or with lansoprazole and clarithromycin to treat certain infections.

What are the side effects of amoxicillin?

Do not take amoxicillin if you are allergic to it or related drugs in the penicillin family such as ampicillin, carbenicillin, dicloxacillin, and oxacillin. In addition, amoxicillin use can result in dangerous complications if you have an allergy to drugs called cephalosporins, asthma, liver or kidney disease, a blood clotting disorder, mononeucleosis, or any other type of allergy.

Severe allergic reactions to amoxicillin will present hives, difficulty breathing, and swelling in the face, lips, tongue, or throat. Other side effects associated with amoxicillin include:
  • Diarrhea
  • Fever
  • Chills
  • Dizziness
  • Heartburn
  • Insomnia
  • Nausea and vomiting
  • Itching
  • Confusion
  • Abdominal pain
  • Easy bruising
  • Bleeding
  • Rash
  • Allergic reactions
  • Urinating less than usual or not at all
  • Seizure
  • Vaginal itching or discharge
  • Thrush (white patches in the mouth)

What drugs should not be taken with amoxicillin?

Amoxicillin is rarely associated with important drug interactions. However, women on birth control pills who use amoxicillin may become pregnant due to a reduction in effectiveness of the birth control. Drugs such as methotrexate, probenecid, sulfa drugs, other antibiotics, and tetracycline antibiotics also may interact with amoxicillin. In addition, antibiotics such as amoxicillin may cause diarrhea. Do not use any medicines to stop the diarrhea unless directed by your doctor. If the diarrhea is watery or bloody, contact your physician.

Written by Peter Crosta M.A.
in http://www.medicalnewstoday.com